Element distributions and crystallographic properties of human bone at <140 nm resolution in 2D and 3D
| Autor: | Palle, Jonas, Wittig, Nina Kølln, Grünewald, Tilman, Kubec, Adam, Burghammer, Manfred, Rosenthal, Martin, Birkedal, Henrik |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Zdroj: | Palle, J, Wittig, N K, Grünewald, T, Kubec, A, Burghammer, M, Rosenthal, M & Birkedal, H 2019, ' Element distributions and crystallographic properties of human bone at <140 nm resolution in 2D and 3D ', International Conferences on the Chemistry and Biology of Mineralized Tissues, Montebello, Canada, 21/10/2019-25/10/2019 . |
| Popis: | Biomineralized tissue such as bone or shells often have a complex hierarchical 3D structure ranging over several length scales. To understand their structure, a method for probing the nanoscale structure in 3D is needed. Bone is particularly challenging due to its' many layers of hierarchical structure in combination with the complex system of osteocyte cells interconnected by canaliculi. Recent developments in synchrotron x-ray focusing optics afford minute x-ray beams, which open opportunities for probing structures at length scales smaller than ever before. Herein, we present how we probe the elemental distribution and crystallographic properties of human bone in 2D and 3D using combined fluorescence and diffraction scattering computed tomography (F-CT and DSCT) [1] with a 50 nm pencil X-ray beam. PURPOSE: This study aims to develop nanoscale 3D multimodal X-ray imaging with the purpose of studying the local chemistry around the mineralization front where new bone is formed, and around canaliculi. METHODS: We conducted multimodal tomography using a nanofocused |
| Databáze: | OpenAIRE |
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