| Zdroj: |
Gonzalez, S F, Degn, S E, Pitcher, L A, Woodruff, M, Heesters, B A & Carroll, M C 2011, ' Trafficking of B cell antigen in lymph nodes ', Annual Review of Immunology, vol. 29, pp. 215-233 . |
| Popis: |
The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation. |
