The effects of hydrogen sulphide on alveolar bone loss in periodontitis
| Autor: | Toker, H., Balci Yüce, H., Goze, F., hakan özdemir, Akpinar, A., Bostanci, V. |
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| Přispěvatelé: | Toker, H., Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey -- Balci Yüce, H., Department of Periodontology, Gaziosmanpaşa University, Faculty of Dentistry, Tokat, Turkey -- Goze, F., Department of Pathology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey -- Ozdemir, H., Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey -- Akpinar, A., Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey -- Bostanci, V., Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Scopus-Elsevier |
| Popis: | Edizioni Minerva Medica Aim. Hydrogen sulphide (H2S), recently considered the third endogenous gaseous transmitter capable of modulating many physiological processes. The purpose of this study was to analyze the morphometric and histopathological changes associated with experimental periodontitis in rats in response to systemic administration of H2S Methods. Forty-eight Wistar rats were divided into six experimental groups: non-ligated (NL) group; ligature only (LO) group; systemic administration of NaHS (H2S donor drug) alone (NaHS) group (14 ?mol/kg body weight per day); and ligature placed and systemic administration of three different doses of NaHS groups (14, 28 and 70 ?mol/kg/day) (L-NaHS-14, L-NaHS-28 and L-NaHS-70, respectively). Silk ligatures were placed at the gingival margin of lower first molars. Changes in alveolar bone levels were clinically measured and tissues were histopathologically examined. Results. At the end of 15 days alveolar bone loss significantly higher in the entire ligature (LO and L-NaHS-14, -28 and -70) groups compared to the unligated groups (P Balci Yüce, H.; Department of Periodontology, Gaziosmanpaşa University, Faculty of Dentistry, Tokat, Turkey; email: htbalci@gmail.com |
| Databáze: | OpenAIRE |
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