Influence of tetrapeptide on chromatin thermostability

Autor:	Monaselidze J, Gorgoshidze M, Jokhadze T, Gaiozishvili M, Teimuraz Lezhava
Rok vydání:	2011
Předmět:	Histones Hot Temperature Liver Animals DNA Oligopeptides Chromatin Nucleosomes Rats
Zdroj:	Scopus-Elsevier Europe PubMed Central
ISSN:	1512-0112
Popis:	It is known that short peptides are capable to interact with DNA, as a result of changes in particular gene expression. In the given work, influence of Ala-Asp-Glu-Leu peptide on thermostability of white rat liver chromatin, in which H1 histone and non-histone proteins are depleted, have been studied. It was shown that in 10 nm chromatin filaments, in which nucleosomas do not interact, the tetrapeptide unfolds the nucleosomal nucleus (core) and this causes release of about 15% of core DNA that melts in the melting temperature range of internucleosomal linker DNA. Thus, the studied tetrapeptide can increase accessibility of DNA for transcription.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f479bb2dc9352c1741dcc6986d970c98 https://pubmed.ncbi.nlm.nih.gov/21685526 Zobrazit plný text záznamu