Evaluation of E6 and E7 mRNA expression in HPV DNA positive breast cancer
| Autor: | Frega, A., Lorenzon, L., Bononi, M., Cesare, A., Antonio Ciardi, Lombardi, D., Assorgi, C., Gentile, M., Moscarini, M., Torrisi, M. R., French, D. |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Papillomavirus E7 Proteins Breast Neoplasms breast cancer hpv hpv 16 e7 e6 Humans Human papillomavirus 31 RNA Messenger Aged Human papillomavirus 16 Human papillomavirus 18 Papilloma Carcinoma Ductal Breast Oncogene Proteins Viral Middle Aged Human papillomavirus 6 DNA-Binding Proteins Repressor Proteins Carcinoma Lobular Fibroadenoma DNA Viral Female |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0392-2936 |
| Popis: | Several studies have suggested a possible role for HPV in the pathogenesis of the breast cancer. We investigated the presence of the HPV DNA in breast cancers and non malignant disease breast tissues by the use of a standard HPV detection method (INNO-Lipa HPV), in order to detect HPV DNA in metastatic nodes, to investigate a possible cervical HPV co-infection, and to evaluate the E6/E7 mRNA expression in HPV DNA positive breast cancer tissues. The rate of HPV infection was significantly higher in the cancer group than in controls (9/31 vs. 0/12, p = 0.04). One out of eight metastatic axillary nodes was positive for HPV infection; 2/3 of the positive HPV breast cancer patients were co-infected at the cervical site. The role of the virus in breast oncogenesis is still unclear, since our analysis failed in demonstrating the expression of viral E6 and E7 in positive HPV positive breast tumor tissues. |
| Databáze: | OpenAIRE |
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