Deimination, Intermediate Filaments and Associated Proteins

Autor:	Briot, Julie, Simon, Michel, Méchin, Marie-Claire
Přispěvatelé:	Unité différenciation épidermique et auto-immunité rhumatoïde (UDEAR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CARBILLET, Véronique
Rok vydání:	2020
Předmět:	filaggrin MESH: Neoplasms / immunology Intermediate Filaments Review Filaggrin Proteins lcsh:Chemistry Arthritis Rheumatoid Intermediate Filament Proteins MESH: Arthritis Rheumatoid / genetics MESH: Arthritis Rheumatoid / immunology [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Neoplasms MESH: Arthritis Rheumatoid / pathology peptidylarginine deiminase lcsh:QH301-705.5 keratin Neurons MESH: Intermediate Filaments / ultrastructure MESH: Protein Multimerization MESH: Intermediate Filaments / enzymology Cell Differentiation Neurodegenerative Diseases cytoskeleton MESH: Protein Processing Post-Translational MESH: Protein-Arginine Deiminases / metabolism MESH: Neoplasms / pathology MESH: Multiple Sclerosis / enzymology [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Protein-Arginine Deiminases / genetics MESH: Neurodegenerative Diseases / genetics MESH: Intermediate Filament Proteins / metabolism MESH: Multiple Sclerosis / genetics MESH: Intermediate Filament Proteins / genetics MESH: Cell Differentiation Multiple Sclerosis citrullination MESH: Neurodegenerative Diseases / immunology MESH: Multiple Sclerosis / immunology MESH: Arthritis Rheumatoid / enzymology MESH: Neurodegenerative Diseases / pathology MESH: Epithelial Cells / pathology MESH: Epithelial Cells / enzymology Humans MESH: Mesenchymal Stem Cells / enzymology MESH: Mesenchymal Stem Cells / pathology MESH: Multiple Sclerosis / pathology MESH: Neurons / enzymology MESH: Humans MESH: Proteolysis Solubility Epithelial Cells Mesenchymal Stem Cells MESH: Neurons / pathology MESH: Neoplasms / enzymology MESH: Neurodegenerative Diseases / enzymology lcsh:Biology (General) lcsh:QD1-999 Solubility post-translational modification MESH: Protein-Arginine Deiminases / chemistry MESH: Neoplasms / genetics Proteolysis Protein-Arginine Deiminases MESH: Citrullination Protein Multimerization MESH: Intermediate Filament Proteins / chemistry Protein Processing Post-Translational
Zdroj:	International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 8746, p 8746 (2020) International Journal of Molecular Sciences, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩ International Journal of Molecular Sciences, MDPI, 2020, 21 (22), pp.8746. ⟨10.3390/ijms21228746⟩
ISSN:	1422-0067 1661-6596
Popis:	International audience; Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis and lupus), cancers and neurodegenerative diseases. Intermediate filaments (IF) and associated proteins (IFAP) are major substrates of PADs. Here, we focus on the effects of deimination on the polymerization and solubility properties of IF proteins and on the proteolysis and cross-linking of IFAP, to finally expose some features of interest and some limitations of citrullinomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dea2c1fa620f63c25246da202a39d52b https://pubmed.ncbi.nlm.nih.gov/33228136 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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