Polymorphic variants INSIG2 rs6726538, HLA‐DRB1 rs9272143, and GCNT1P5 rs7780883 contribute to the susceptibility of cervical cancer in the Bangladeshi women
| Autor: | Hasan, Md. Emtiaz, Matin, Maliha, Haque, Md. Enamul, Aziz, Md. Abdul, Millat, Md. Shalahuddin, Uddin, Mohammad Sarowar, Moghal, Md. Mizanur Rahman, Islam, Mohammad Safiqul |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Genotyping Techniques cervical cancer HLA‐DQB1 HLA‐DRB1 Uterine Cervical Neoplasms Polymerase Chain Reaction Polymorphism Single Nucleotide INSIG2 Confidence Intervals Odds Ratio Humans Genetic Predisposition to Disease RC254-282 Original Research Cancer Biology Aged Aged 80 and over Intracellular Signaling Peptides and Proteins Membrane Proteins Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged Case-Control Studies GCNT1P5 Female T‐ARMS‐PCR Genome-Wide Association Study HLA-DRB1 Chains |
| Zdroj: | Cancer Medicine, Vol 10, Iss 5, Pp 1829-1838 (2021) Cancer Medicine |
| ISSN: | 2045-7634 |
| Popis: | Objective Cervical cancer is a gynecological health problem, affecting nearly 500,000 women each year worldwide. Genome‐wide association studies have revealed multiple susceptible genes and their polymorphisms for cervical carcinoma risk. We have carried out this case‐control study to investigate the association of INSIG2 rs6726538 (A; T), HLA‐DRB1 rs9272143 (T; C), and GCNT1P5 rs7780883 (G; A) with cervical cancer. Methods The present study recruited 234 cervical cancer patients as cases and 212 healthy females as controls. We have applied the tetra‐primer amplification refractory mutation system polymerase chain reaction (T‐ARMS‐PCR) method for genotyping. Results The SNP rs6726538 was significantly associated with increased risk of cervical cancer in all genetic models (AT vs. AA: OR = 3.30, 95% CI = 2.19–4.97, p Cervical cancer (CC) is a gynecological health problem, affecting nearly 500,000 women each year worldwide. The present study recruited 234 cervical cancer patients as cases and 212 healthy females as controls. Our study concludes that rs6726538, rs9272143, and rs7780883 polymorphisms may contribute to the development of CC in the Bangladeshi population. |
| Databáze: | OpenAIRE |
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