Epidemiology of human cytomegalovirus strains through comparison of methodological approaches to explore gN variants

Autor:	Pignatelli, S., PAOLA DAL MONTE
Přispěvatelé:	Pignatelli S., Dal Monte P.
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	Base Sequence Molecular Sequence Data Infant Newborn Cytomegalovirus Genetic Variation Infant Sequence Analysis DNA Polymerase Chain Reaction Viral Envelope Proteins Child Preschool Cytomegalovirus Infections Humans Female Child Polymorphism Restriction Fragment Length
Zdroj:	Europe PubMed Central Scopus-Elsevier
Popis:	Genomic variation among human cytomegalovirus (HCMV) wild-type strains is a well-documented phenomenon probably implicated in HCMV-induced immunopathogenesis. Extensive genetic polymorphism has been detected for the envelope glycoprotein N (gN) and HCMV clinical isolates have been clustered into seven distinct gN variants (gN-1, gN-2, gN-3a, gN-3b, gN-4a, gN-4b, gN-4c). Several studies from different research groups worldwide have addressed this topic using different methodological approaches (PCR-RFLP, PCR-Cloning, PCR-Sequencing) and sometimes yielding apparently conflicting results. This paper analyses the epidemiology of HCMV strains through analysis of gN variants, criticizing the methodological approaches and study populations by comparison of published reports.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d7c90b213735df9fbcad553034be295c http://hdl.handle.net/11585/82853 Zobrazit plný text záznamu