Pentraxin 3 serum levels in children with atopic dermatitis

Autor:	Marseglia, G. L., Amici, M., Marseglia, A., Caimmi, S., Miraglia Del Giudice, M., Leoni, M. C., Salpietro, C., Leonardi, S., Ilaria Brambilla, Ciprandi, G.
Přispěvatelé:	Marseglia, Gl, DE AMICI, M, Marseglia, A, Caimmi, S, MIRAGLIA DEL GIUDICE, Michele, Leoni, Mc, Salpietro, C4, Leonardi, S, Brambilla, I, Ciprandi, G.
Předmět:	Male PENTRAXIN 3 atopic dermatitis respiratory allergy Serum Amyloid P-Component C-Reactive Protein Adolescent Humans Female Child Dermatitis Atopic
Zdroj:	Europe PubMed Central Scopus-Elsevier
Popis:	PTX3 behaves as an acute-phase response protein as its blood levels rapidly and dramatically increase during endotoxic shock, sepsis, and other inflammatory and infectious conditions. Therefore, this study was designed to investigate a possible role of PTX3 in children with Atopic Dermatitis (AD). One-hundred-and-thirty-six patients (37 females, 99 males, mean age 10.4 years) were enrolled in the study. One hundred patients (74%) had only respiratory symptoms (allergic rhinitis and/or bronchial asthma); thirty-six patients (26%) showed dermatitis associated with respiratory allergy (allergic rhinitis and/or bronchial asthma). PTX3 levels were higher in children with AD and there was a significant correlation between serum PTX3 levels and SCORAD index (p-value=0.0001, rho=0.658). Therefore, this study may show that PTX3 might be a reliable marker for the severity of AD in children with respiratory allergy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d0e77984c475518872e10ca18cebdad1 http://europepmc.org/abstract/med/22691256 Zobrazit plný text záznamu