Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice
Autor: | Camelo, S., Calippe, B., Lavalette, S., Dominguez, E., Hur, J., Devevre, E., Guillonneau, X., William Raoul, Sennlaub, F. |
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Přispěvatelé: | Unité de Recherche Clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de la Vision, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017] (GICC UMR 7292 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), ERC-2007 St.G. 210345, Raoul, William, Université de Tours-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Lariboisière, Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Centre de Recherche des Cordeliers ( CRC (UMR_S 872) ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Génétique, Immunothérapie, Chimie et Cancer ( GICC ), Université de Tours-Centre National de la Recherche Scientifique ( CNRS ), Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
cis-trans-Isomerases
Aging Light genetic structures Retinal Pigment Epithelium Chemokine CXCL9 Mice Cell Movement Animals Humans RNA Messenger [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs Choroid Photochemical Processes eye diseases Chemokine CXCL10 Mice Inbred C57BL Oxidative Stress Gene Expression Regulation [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] [ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] sense organs T-Lymphocytes Cytotoxic Research Article |
Zdroj: | Molecular Vision Molecular Vision, 2015, 21, pp.1051-9 Europe PubMed Central Scopus-Elsevier Molecular Vision, Molecular Vision, 2015, 21, pp.1051-9 |
ISSN: | 1090-0535 |
Popis: | International audience; The choroidal vasculature is essential when it comes to bringing oxygen and nutrients to the functioning retina and evacuating debris resulting from the normal visual cycle. Choroidal thinning is a common feature in many human eye diseases, including high myopia [1,2] and retinitis pigmentosa [3,4], and has been reproducibly observed with age [5-7]. However, the association between choroidal thinning and age-related macular degeneration (AMD) remains controversial. Some authors have reported the loss of choriocapillaries in eyes with exudative AMD [8], and choroidal thinning has been detected in some studies [9-11]. Choroidal thinning has also been associated with geographic atrophy (GA), the dry form of late AMD [12-15]. A morphometric analysis by Ramrattan et al. more than two decades ago showed a decrease in choriocapillary density and diameter with age and in GA, but choroidal thinning was only significant with age [6]. Moreover, it has been reported that the choriocapillaries and choroid are thinner in areas where the RPE has degenerated [8]. However, all studies agree that aging is associated with significant choroidal thinning [16-18]. The exact mechanisms behind choroidal thinning with age or disease are not clear. The RPE is a monolayer of pigmented cells situated between photoreceptors and Bruch's membrane; its plays an essential role in the visual cycle. RPE65, which is also called 11-cis retinol isomerase and is strongly expressed in the RPE, participates in the production of 11-cis retinal [19], which is essential for photoreceptor function [20]. Mutations in the RPE65 gene cause progressive photoreceptor degeneration [21,22] and adult RPE65 −/− |
Databáze: | OpenAIRE |
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