[THE INFLUENCE OF HYDROGEN SULFIDE ON COLLAGEN-INDUCED AGGREGATION OF HUMAN PLATELETS]
| Autor: | Iv, Petrova, Oa, Trubacheva, Os, Mangataeva, Te, Suslova, Iv, Kovalev, Svetlana Gusakova |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Platelets Male Glycosylation Nitric Oxide Synthase Type III Platelet Aggregation Gasotransmitters Phosphodiesterase Inhibitors Colforsin Primary Cell Culture Middle Aged Sulfides Nitric Oxide Protein Carbonylation Diabetes Mellitus Type 2 Case-Control Studies Cyclic AMP Humans Calcium Female Nitric Oxide Donors Collagen Hydrogen Sulfide Oxidation-Reduction Platelet Aggregation Inhibitors |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0869-8139 |
| Popis: | Study the impact of hydrogen sulfide on collagen-induced platelet aggregation from healthy donors and patients with type 2 diabetes. In healthy individuals, in contrast to patients with type 2 diabetes, NaHS significantly inhibited platelet aggregation. Activators of cAMP signaling (forskolin and phosphodiesterase inhibitor) significantly reduced platelet aggregation in both groups of examinees. NO-synthase inhibitors increased platelet aggregation in healthy volunteers, but not in patients with type 2 diabetes. The presence of H2S donor did not alter the extent of platelet aggregation at high concentrations of cAMP or decreased production of nitric oxide. It is assumed that the antiplatelet effect of H2S is not associated with the effect on the signal system, mediated cAMP or nitric oxide. Change H2S-dependent regulation of platelet aggregation in patients with type 2 diabetes is caused by disorders have been reported with this disease: the increase of intracellular calcium ion concentration, oxidative damage to proteins, hyperhomocysteinemia, glycosylation of key proteins involved in this process. |
| Databáze: | OpenAIRE |
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