No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV
| Autor: | Ramezani, A., Saboori, E., Azadmanesh, K., Mohraz, M., Monireh Kazemimanesh, Karami, A., Banifazl, M., Golchehregan, H., Aghakhani, A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Iranian Journal of Public Health Scopus-Elsevier Iranian Journal of Public Health, Vol 45, Iss 7, Pp 935-940 (2016) |
| ISSN: | 2251-6093 2251-6085 |
| Popis: | Background: Kaposi’s sarcoma is a vascular malignancy, which frequently occurs among immunocompromised individuals such as transplant recipients and patients with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) is considered the etiological agent of all forms of Kaposi’s sarcoma. Though some seroepidemiological studies conducted on the prevalence of HHV-8 in Iran, there are insufficient data on the prevalence of HHV-8 viremia in HIV infected patients. We therefore, aimed to determine the prevalence of HHV-8 viremia in general population and HIV infected patients without Kaposi’s sarcoma in Tehran, Iran.Methods: We conducted a cross sectional survey on 99 patients with HIV infection referred to Iranian Research Center for HIV/AIDS and 40 healthy controls in Tehran, Iran from January to April 2014. The presence of HHV-8 DNA was detected in buffy coat samples of enrolled subjects using nested PCR assay.Results: A total of 99 HIV infected patients with mean age of 37.9±10 yr and 40 healthy controls with mean age of 39±11.5 yr were enrolled in the study. The mean CD4 count was 410.3± 211.4 cells/mm3. HHV-8 DNA was not detected in both healthy control and HIV patient groups.Conclusion: This survey showed low rate of HHV-8 DNA in healthy controls and HIV patients. Considering our findings HHV-8 infection does not seem to be widespread in our population. Further studies focusing on different regions of Iran appear to be required to have a more accurate estimation. Keywords: Human immunodeficiency virus (HIV), Human herpesvirus 8 (HHV-8), Prevalence, Viremia, Iran |
| Databáze: | OpenAIRE |
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