Evaluation of the use of partition coefficients and molecular surface properties as predictors of drug absorption: a provisional biopharmaceutical classification of the list of national essential medicines of Pakistan

Autor:	ramzi shawahna, Rahman, N. U.
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	PSA Biopharmaceutical classification system Original Article log D Permeability log P
Zdroj:	DARU : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences Scopus-Elsevier
ISSN:	2008-2231 1560-8115
Popis:	Background and the purpose of the study Partition coefficients (log D and log P) and molecular surface area (PSA) are potential predictors of the intestinal permeability of drugs. The aim of this investigation was to evaluate and compare these intestinal permeability indicators. Methods Aqueous solubility data were obtained from literature or calculated using ACD/Labs and ALOGPS. Permeability data were predicted based on log P, log D at pH 6.0 (log D6.0), and PSA. Results Metoprolol's log P, log D6.0, and a PSA of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ba2dcd623a7f74b71f548bac0d28ed10 http://europepmc.org/articles/PMC3232101 Zobrazit plný text záznamu