Involvement of primary afferent nerves after abdominal irradiation: consequences on ileal contractile activity and inflammatory mediator release in the rat
| Autor: | Linard, Christine, Marquette, C., Strup, Carine, Aigueperse, Jocelyne, Mathe, Denis |
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| Přispěvatelé: | Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Section Autonome de Radiobiologie Appliquée à la Médecine (IRSN/DPHD/SARAM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Département de Protection et de santé de l'Homme et de Dosimétrie, Section Autonome de Radiobiologie Appliquée à la Médecine |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
MESH: Capsaicin MESH: Substance P MESH: Rats [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology MESH: Inflammation Mediators MESH: Neurotensin Substance P Ileum Animals MESH: Animals Neurons Afferent Rats Wistar Neurotensin Nerve Endings Tumor Necrosis Factor-alpha MESH: Neurons Afferent MESH: Interleukin-1 MESH: Rats Wistar MESH: Male Rats Radiation Injuries Experimental MESH: Nerve Endings MESH: Radiation Injuries Experimental MESH: Tumor Necrosis Factor-alpha MESH: Ileum MESH: Gastrointestinal Motility Capsaicin Inflammation Mediators Gastrointestinal Motility Interleukin-1 |
| Zdroj: | Digestive Diseases and Sciences Digestive Diseases and Sciences, 2003, 48 (4), pp.688-97 Digestive Diseases and Sciences, Springer Verlag, 2003, 48 (4), pp.688-97 |
| ISSN: | 0163-2116 1573-2568 |
| Popis: | International audience; In this study we analyzed the role of substance P (SP) from afferent nerves in ileum contractibility and in the release of inflammatory mediators (neurotensin, Il-1beta, and TNF-alpha) in ileal mucosa and muscularis layers after a 10-Gy gamma-irradiation of the abdomen. Six hours after irradiation, SP concentrations were lower than in control rats, and 3 days after irradiation SP-induced contractile activity was higher. Irradiation significantly increased the levels of neurotensin, Il-1beta, and TNF-alpha in both layers. Pretreatment with capsaicin depleted afferent nerve endings of SP and reduced SP levels by about 50%. Capsaicin treatment reduced SP concentrations further, beyond the levels due to irradiation, thereby suggesting that all sources of SP are affected by irradiation. Capsaicin treatment prevented the irradiation from affecting SP-induced contractile response or increasing neurotensin levels. This finding suggests that SP released by afferent nerve endings controls these functions. Proinflammatory cytokine release was not reduced by capsaicin treatment. |
| Databáze: | OpenAIRE |
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