Retinal phototoxicity and the evaluation of the blue light hazard of a new solid-state lighting technology

Autor: Jaadane, Imene, Villalpando Rodriguez, Gloria, Boulenguez, Pierre, Carré, Samuel, Dassieni, Irene, Lebon, Cecile, Chahory, Sabine, Behar-Cohen, Francine, Martinsons, Christophe, Torriglia, Alicia
Přispěvatelé: Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Unité d'ophtalmologie [Maisons-Alfort], École nationale vétérinaire d'Alfort (ENVA), Centre Scientifique et Technique du Bâtiment (CSTB), This work was supported by ADEME (grant UV-LED), INSERM, CSTB and ENVA., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), École nationale vétérinaire - Alfort (ENVA), Bodescot, Myriam
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.6733. ⟨10.1038/s41598-020-63442-5⟩
ISSN: 2045-2322
DOI: 10.1038/s41598-020-63442-5
Popis: International audience; Exposure Limit Values (ELV) for artificial lighting were defined in order to prevent light-induced damage to the retina. The evaluation of the lighting devices include the correction of their spectra by the B(λ) function or blue light hazard function, representing the relative spectral sensitivity of the human eye to the blue light. This weighting function peaks between 435 and 440 nm. In this study we evaluate a new generation of light emitting diode (LED), the GaN-on-GaN (gallium nitride on gallium nitride) LED, that present an emission peak in the purple part of the spectrum. Wistar rats were exposed to GaN-on-GaN and conventional diodes at different retinal doses (from 2.2 to 0.5 J/cm2). We show that GaN-on-GaN diodes are more toxic than conventional LED for the rat neural retina and the rat retinal pigment epithelium, indicating that the BLH (blue light hazard) weighting is not adapted to this type of diodes. One of the reasons of this increased toxicity is the effects of shorter wavelengths on mitochondria polarization. We also show that the threshold of phototoxic retinal dose in the rat (fixed at 11 J/cm2, BLH weighted) is overestimated, suggesting that the values used for regulations, calculated in primates using the same methods than in rats, should be revised.
Databáze: OpenAIRE
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