Association of myostatin, a cytokine released by muscle, with inflammation in rheumatoid arthritis
| Autor: | Murillo-Saich, Jessica D., Vazquez-Villegas, Maria Luisa, Ramirez-Villafaña, Melissa, Saldaña-Cruz, Ana Miriam, Aceves-Aceves, Javier A., Gonzalez-Lopez, Laura, Guma, Monica, Gamez-Nava, Jorge I. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
rheumatoid arthritis
Adult muscle Observational Study Arthritis Rheumatoid Young Adult Humans Rheumatoid arthritis diseases activity Aged Aged 80 and over Inflammation Rheumatoid cachexia Middle Aged Myostatin myopenia Cross-Sectional Studies Case-Control Studies Myopenia Diseases activity ComputingMethodologies_DOCUMENTANDTEXTPROCESSING rheumatoid cachexia Muscle Female Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Supplemental Digital Content is available in the text Myostatin is a cytokine produced and released by myocytes that might have an outstanding role not only in muscle wasting during cachexia but also in inflammation. Herein we explore the association between myostatin levels and inflammatory parameters in rheumatoid arthritis (RA). One hundred twenty-seven women without rheumatic diseases and 84 women with a diagnosis of RA were assessed in a cross-sectional study. Outcomes reflecting the activity of the arthritis including Disease Activity Score (DAS28-ESR) and impairment in functioning by the Health Assessment Questionnaire-Disability Index were assessed in RA. We obtained Skeletal muscle mass index (SMI), fat-free mass index (FFMI), and fat mass index using dual-energy x-ray absorptiometry. Serum myostatin was determined by enzyme-linked immunosorbent assay. Myostatin levels were correlated with disease activity and parameters of muscle mass. The SMI was lower and concentration of myostatin was higher in RA patients than in controls (P = .008 and P |
| Databáze: | OpenAIRE |
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