Specific effects exerted by B-lymphoproliferative diseases on peripheral T-lymphocytes protein expression

Autor: Borro, Marina, Gentile, Giovanna, De Luca, Ottavia, Aimati, Laura, Torre, Maria Simona, Tatarelli, Caterina, Aloe Spiriti, Maria Antonietta, Cox, Maria Christina, Simmaco, Maurizio
Přispěvatelé: 2nd Faculty of Medicine, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Unit of Advanced Molecular Diagnostics, Sant'Andrea Hospital, Haematology
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: British Journal of Haematology
British Journal of Haematology, Wiley, 2010, ⟨10.1111/j.1365-2141.2010.08285.x⟩
ISSN: 0007-1048
1365-2141
DOI: 10.1111/j.1365-2141.2010.08285.x⟩
Popis: International audience; A proteomic approach was applied to study the protein expression profile of peripheral T-cells derived from patients at the onset of different B-lymphoproliferative diseases, since a rising interest in specific actions played by T-cells in such pathologies has emerged. Decreased levels of profilin-1 and cofilin-1 and increased levels of coronin1A and prohibitin were found in patients, compared with healthy controls. The protein-protein interaction network of these proteins was studied using a web-based bioinformatics tool, highlighting the actin cytoskeleton regulation as the main biological process involved in peripheral T-cells of such patients. Unsupervised cluster analysis of protein expression data shows that the recorded alteration of T-cell proteome was specifically induced by B-cells pathologies.
Databáze: OpenAIRE
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