Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics?
| Autor: | Madjdpour, C, Dettori, N, Frascarolo, P, Burki, M, Boll, M, Fisch, A, Bombeli, T, Spahn, D R |
|---|---|
| Přispěvatelé: | University of Zurich, Spahn, D R |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Swine
Plasma Substitutes 610 Medicine & health Blood Viscosity 142-005 142-005 Thrombelastography Hydroxyethyl Starch Derivatives Molecular Weight Animals 2703 Anesthesiology and Pain Medicine biological phenomena cell phenomena and immunity Blood Coagulation reproductive and urinary physiology Blood Coagulation/drug effects Blood Viscosity/drug effects Hydroxyethyl Starch Derivatives/blood Hydroxyethyl Starch Derivatives/chemistry Hydroxyethyl Starch Derivatives/pharmacology Plasma Substitutes/chemistry Plasma Substitutes/pharmacokinetics Plasma Substitutes/pharmacology |
| Zdroj: | British Journal of Anaesthesia, vol. 94, no. 5, pp. 569-576 |
| Popis: | Background. The development of hydroxyethyl starches (HES) with low impact on blood coagulation but higher volume effect compared with the currently used HES solutions is of clinical interest. We hypothesized that high molecular weight, low-substituted HES might possess these properties. Methods. Thirty pigs were infused with three different HES solutions (20 ml kg−1) with the same degree of molar substitution (0.42) but different molecular weights (130, 500 and 900 kDa). Serial blood samples were taken over 24 h and blood coagulation was assessed by Thromboelastograph® analysis and analysis of plasma coagulation. In addition, plasma concentration and in vivo molecular weight were determined and pharmacokinetic data were computed based on a two-compartment model. Results. Thromboelastograph analysis and plasma coagulation tests did not reveal a more pronounced alteration of blood coagulation with HES 500 and HES 900 compared with HES 130. In contrast, HES 500 and HES 900 had a greater area under the plasma concentration-time curve [1542 (142) g min litre−1, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|