[The methods for the protection against counterfeit medications. Part 1. The estimation of the quality of metoprolol succinate substance and tablets from different manufacturers in terms of 'identity' and 'active ingredient content']

Autor:	Va, Iakushev, Margarita Morozova, Te, Elizarova, Sb, Fitilev, Tv, Pletneva
Rok vydání:	2012
Předmět:	Pharmacopoeias as Topic Quality Control Sweden Spectroscopy Near-Infrared Drug Industry Counterfeit Drugs Chemistry Pharmaceutical Calibration Discriminant Analysis Poland Metoprolol Russia Tablets
Zdroj:	Europe PubMed Central
ISSN:	0039-4521
Popis:	This paper was designed to report the results of analysis of metoprolol succinate substance and tablets obtained from two manufacturers, Akrikhin (Russia) and AstraZeneca (Sweden). The analysis was performed by spectroscopy in the near IR region and followed by the chemometric treatment of the data obtained. The method was used to confirm the "identity" of metoprolol succinate tablets. The approach to distinguishing the differences between pharmaceutical dosage forms produced by different manufacturers is proposed. Also, the method for the qualitative determination of metoprolol succinate in the pharmaceutical formulations has been developed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::841c35bc15365667d4ce6d891807b8d7 https://pubmed.ncbi.nlm.nih.gov/23008961 Zobrazit plný text záznamu