Effect of antipsychotic drugs on life quality of schizophrenic patients: one year follow-up study

Autor: Fang, Maosheng, Li, Lehua, Zhao, Jingping, Chen, Honghui, Ye, Meng, Guo, Xiaofeng, Lu, Zheng, Sun, Xueli, Chuan-Yue Wang, Xie, Shiping, Hu, Bin, Guo, Tiansheng, Ma, Cui, Wang, Bo, Lu, Luxian, Liu, Na, Deng, Hong, Chen, Qi, Shang, Xiaofang, Gong, Fajin, Zhang, Xiyan, He, Xiaolin, Zhou, Jianchu, Zhang, Yingli
Předmět:
Zdroj: ResearcherID
Popis: To compare the effect of 7 antipsychotic drugs on the life quality of schizophrenia patients including chlorpromazine, sulpiride, clozapine, risperidone, olanzapine, quetiapine, and aripiprazole.A total of 1,227 stable schizophrenic patients within 5 years onset who took 1 of the 7 study medications as maintenance treatment were followed up for 1 year at 10 China sites. Patients were evaluated by the short form-36 health survey (SF-36) at the baseline and at the end of 1 year.The life quality was improved obviously at the end of the follow-up. There was significant difference in body pain, vitality, and mental health (P0.05) among these antipsychotic drugs.All 7 antipsychotic drugs can improve the life quality of schizophrenia patients. Atypical antipsychotic drugs, especially olazapine and quetiapine, are superior to typical antipsychotic drugs in improving life quality.
Databáze: OpenAIRE