Unexpected Interacting Effects of Physical (Radiation) and Chemical (Bisphenol A) Treatments on Male Reproductive Functions in Mice
| Autor: | Margaux Wieckowski, Stéphanie Ranga, Delphine Moison, Sébastien Messiaen, Sonia Abdallah, Sylvie Granon, René Habert, Virginie Rouiller-Fabre, Gabriel Livera, Marie-Justine Guerquin |
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| Přispěvatelé: | Stabilité génétique, cellules souches et radiations (SGCSR (U_1274 / UMR_E_008)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
Male
endocrine system germ cells γ-ray QH301-705.5 MESH: Leydig Cells Article MESH: Prenatal Exposure Delayed Effects reproduction Mice MESH: Phenols MESH: Pregnancy Bisphenol A Phenols Pregnancy MESH: Benzhydryl Compounds Animals Humans MESH: Animals Biology (General) Benzhydryl Compounds QD1-999 MESH: Mice [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health MESH: Humans Leydig Cells MESH: Gamma Rays MESH: Male Chemistry Radiation Injuries Experimental endocrine disruptors Gamma Rays MESH: Radiation Injuries Experimental [SDV.TOX]Life Sciences [q-bio]/Toxicology Prenatal Exposure Delayed Effects MESH: HeLa Cells Female MESH: Female HeLa Cells |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, 2021, 22 (21), pp.11808. ⟨10.3390/ijms222111808⟩ Volume 22 Issue 21 International Journal of Molecular Sciences, Vol 22, Iss 11808, p 11808 (2021) |
| ISSN: | 1422-0067 1661-6596 |
| DOI: | 10.3390/ijms222111808⟩ |
| Popis: | International audience; For decades, numerous chemical pollutants have been described to interfere with endogenous hormone metabolism/signaling altering reproductive functions. Among these endocrine disrupting substances, Bisphenol A (BPA), a widely used compound, is known to negatively impact germ and somatic cells in the testis. Physical agents, such as ionizing radiation, were also described to perturb spermatogenesis. Despite the fact that we are constantly exposed to numerous environmental chemical and physical compounds, very few studies explore the impact of combined exposure to chemical and physical pollutants on reproductive health. The aim of this study was to describe the impact of fetal co-exposure to BPA and IR on testicular function in mice. We exposed pregnant mice to 10 µM BPA (corresponding to 0.5 mg/kg/day) in drinking water from 10.5 dpc until birth, and we irradiated mice with 0.2 Gy (γ-ray, RAD) at 12.5 days post-conception. Co-exposure to BPA and γ-ray induces DNA damage in fetal germ cells in an additive manner, leading to a long-lasting decrease in germ cell abundance. We also observed significant alteration of adult steroidogenesis by RAD exposure independently of the BPA exposure. This is illustrated by the downregulation of steroidogenic genes and the decrease of the number of adult Leydig cells. As a consequence, courtship behavior is modified, and male ultrasonic vocalizations associated with courtship decreased. In conclusion, this study provides evidence for the importance of broadening the concept of endocrine disruptors to include physical agents, leading to a reevaluation of risk management and regulatory decisions. |
| Databáze: | OpenAIRE |
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