Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus

Autor:	Parthena, Meltzanidou, Aikaterini, Patsatsi, Aikaterini, Kyriakou, Katerina, Vareli, Alexandros, Lambropoulos
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Desmocollins Greece integumentary system Case-Control Studies Immunoglobulin G biological sciences technology industry and agriculture Humans lipids (amino acids peptides and proteins) skin and connective tissue diseases Pemphigus Autoantibodies
Zdroj:	Acta Dermatovenerologica Croatica Volume 27 Issue 1
ISSN:	1847-6538 1330-027X
Popis:	Pemphigus is an autoimmune bullous disorder caused by autoantibodies against desmosomal cadherins. The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desmocollin-3 (Dsc-3) has been initially reported to participate in epidermal blistering in mice. There have been reports in which autoantibodies against Dsc-3 have been detected. In PV, a limited number of studies found no presence of IgG or IgA autoantibodies against Dsc-3. In this study we examined sera from Greek patients with PV and PF for the presence of IgG autoantibodies against Dsc-3. Immunoblotting for the detection of autoantibodies against Dsc-3 was performed in sera from all cases. Dsc-3 autoantibodies were not detected in either group (PV and PF). Our results confirm the hypothesis that the pathogenic role of Dsc-3 in epidermal blistering in PV and PF remains controversial.
Databáze:	OpenAIRE
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