Wnt evolution and function shuffling in liberal and conservative chordate genomes

Autor: Somorjai, Ildiko M. L., Marti-Solans, Josep, Diaz-Gracia, Miriam, Nishida, Hiroki, Imai, Kaoru, Escriva, Hector, Cañestro, Cristian, Albalat, Ricard
Přispěvatelé: University of St Andrews [Scotland], Universitat de Barcelona (UB), Osaka University [Osaka], Biologie intégrative des organismes marins (BIOM), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Banyuls (OOB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Universitat de Barcelona, European Commission, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. Marine Alliance for Science & Technology Scotland, University of St Andrews. School of Biology, University of St Andrews. Scottish Oceans Institute
Rok vydání: 2018
Předmět:
Zdroj: Genome Biology
Genome Biology, BioMed Central, 2018, 19 (1), ⟨10.1186/s13059-018-1468-3⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 1474-760X
1465-6906
DOI: 10.1186/s13059-018-1468-3⟩
Popis: IS was supported by the European Union Horizon 2020 research and innovation programme under grant agreement numbers 654428 (“CORBEL”). HN was supported by Grants in Aid from The Japan Society for The Promotion of Science (22370078, 15H04377) and The Ministry of Education, Culture, Sports, Science and Thechnology, Japan (23112714, 25113518). KI was supported by a Grant in Aid from the Japan Society for the Promotion of Science (26711014). HE was supported by ANR-16-CE12-0008-01 grant from Agence Nationale de la Recherche. CC was supported by BFU2016-80601-P. RA was supported by BIO2015-67358-C2-1-P grant from Ministerio de Economía y Competitividad (Spain). CC and RA were also supported by grants BFU2010-14875 from Ministerio de Ciencia e Innovación (Spain), and SGR2014-290 and SGR2017-1665 from Generalitat de Catalunya. Background: What impact gene loss has on the evolution of developmental processes, and how function shuffling has affected retained genes driving essential biological processes, remain open questions in the fields of genome evolution and EvoDevo. To investigate these problems, we have analyzed the evolution of the Wnt ligand repertoire in the chordate phylum as a case study. Results: We conduct an exhaustive survey of Wnt genes in genomic databases, identifying 156 Wnt genes in 13 non-vertebrate chordates. This represents the most complete Wnt gene catalog of the chordate subphyla and has allowed us to resolve previous ambiguities about the orthology of many Wnt genes, including the identification of WntA for the first time in chordates. Moreover, we create the first complete expression atlas for the Wnt family during amphioxus development, providing a useful resource to investigate the evolution of Wnt expression throughout the radiation of chordates. Conclusions: Our data underscore extraordinary genomic stasis in cephalochordates, which contrasts with the liberal and dynamic evolutionary patterns of gene loss and duplication in urochordate genomes. Our analysis has allowed us to infer ancestral Wnt functions shared among all chordates, several cases of function shuffling among Wnt paralogs, as well as unique expression domains for Wnt genes that likely reflect functional innovations in each chordate lineage. Finally, we propose a potential relationship between the evolution of WntA and the evolution of the mouth in chordates. Publisher PDF
Databáze: OpenAIRE
Externí odkaz: