Learning deficits in rats overexpressing the dopamine transporter
| Autor: | Bernhardt, Nadine, Lieser, Maike Kristin, Hlusicka, Elizabeth-Barroeta, Habelt, Bettina, Wieske, Franziska, Edemann-Callesen, Henriette, Garthe, Alexander, Winter, Christine |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Dopamine Neurogenesis lcsh:Medicine metabolism [Hippocampus] Motor Activity Hippocampus Rats Sprague-Dawley physiology [Maze Learning] Animals metabolism [Dopamine] Maze Learning lcsh:Science Neurons Dopamine Plasma Membrane Transport Proteins Memory Disorders metabolism [Learning Disabilities] Learning Disabilities metabolism [Corpus Striatum] lcsh:R metabolism [Memory Disorders] physiology [Neurogenesis] Corpus Striatum Rats physiology [Motor Activity] metabolism [Neurons] metabolism [Dopamine Plasma Membrane Transport Proteins] lcsh:Q ddc:600 |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) Scientific reports 8(1), 14173 (2018). doi:10.1038/s41598-018-32608-7 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-32608-7 |
| Popis: | With its capacity to modulate motor control and motivational as well as cognitive functions dopamine is implicated in numerous neuropsychiatric diseases. The present study investigated whether an imbalance in dopamine homeostasis as evident in the dopamine overexpressing rat model (DAT-tg), results in learning and memory deficits associated with changes in adult hippocampal neurogenesis. Adult DAT-tg and control rats were subjected to the Morris water maze, the radial arm maze and a discrimination reversal paradigm and newly generated neurons in hippocampal circuitry were investigated post mortem. DAT-tg rats were found to exhibit a striking inability to acquire information and deploy spatial search strategies. At the same time, reduced integration of adult-born neurons in hippocampal circuitry was observed, which together with changes in striatal dopamine signalling might explain behavioural deficits. |
| Databáze: | OpenAIRE |
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