Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system
| Autor: | Elmir, Omerovic, Rodolfo, Citro, Eduardo, Bossone, Bjorn, Redfors, Johannes, Backs, Bastian, Bruns, Michele, Ciccarelli, Liam S, Couch, Dana, Dawson, Guido, Grassi, Massimo, Iacoviello, Guido, Parodi, Birke, Schneider, Christian, Templin, Jelena R, Ghadri, Thomas, Thum, Ovidiu, Chioncel, C Gabriele, Tocchetti, Jolanda, van der Velden, Stephane, Heymans, Alexander R, Lyon |
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| Přispěvatelé: | Omerovic, Elmir, Citro, Rodolfo, Bossone, Eduardo, Redfors, Bjorn, Backs, Johanne, Bruns, Bastian, Ciccarelli, Michele, Couch, Liam S, Dawson, Dana, Grassi, Guido, Iacoviello, Massimo, Parodi, Guido, Schneider, Birke, Templin, Christian, Ghadri, Jelena R, Thum, Thoma, Chioncel, Ovidiu, Tocchetti, Carlo Gabriele, Van Der Velden, Jolanda, Heymans, Stephane, Lyon, Alexander R, Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, van der Velden, J, Heymans, S, Lyon, A, University of Zurich, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Sympathetic Nervous System
Cardiac & Cardiovascular Systems TAKO-TSUBO CARDIOMYOPATHY G protein coupled receptor kinase Takotsubo syndrome beta-adrenergic signaling catecholamine electrophysiology inflammation metabolism pathophysiology DIAGNOSTIC-CRITERIA BALLOONING SYNDROME Cardiology 610 Medicine & health Pathophysiology Catecholamines Takotsubo Cardiomyopathy STRESS-INDUCED CARDIOMYOPATHY Humans Beta-adrenergic signalling G-protein coupled receptor kinase Heart Failure Inflammation VENTRICULAR DYSFUNCTION Science & Technology NATRIURETIC PEPTIDE CLINICAL-FEATURES COUPLED-RECEPTOR KINASE-5 Electrophysiology Metabolism QT INTERVAL PROLONGATION 10209 Clinic for Cardiology Cardiovascular System & Cardiology Catecholamine LIFE-THREATENING ARRHYTHMIAS Life Sciences & Biomedicine |
| Zdroj: | European journal of heart failure, 24(2), 257-273. Wiley |
| ISSN: | 1388-9842 |
| Popis: | This is the first part of a scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome and is complimentary to the previous HFA position statement on Takotsubo syndrome which focused upon clinical management. In part 1 we provide an overview of the pathophysiology of Takotsubo syndrome and fundamental questions to consider. We then review and discuss the central role of catecholamines and the sympathetic nervous system in the pathophysiology, and the direct effects of high surges in catecholamines upon myocardial biology including β-adrenergic receptor signalling, G-protein coupled receptor kinases, cardiomyocyte calcium physiology, myofilament physiology, cardiomyocyte gene expression, myocardial electrophysiology and arrhythmogenicity, myocardial inflammation, metabolism and energetics. The integrated effects upon ventricular haemodynamics are discussed and integrated into the pathophysiological model. ispartof: EUROPEAN JOURNAL OF HEART FAILURE vol:24 issue:2 pages:257-273 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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