| Autor: |
Margarita Morozova, Ge, Rupchev, Ig, Kozhekin, Tb, Arsenieva, Ra, Cheremin, Vn, Yachmenev, Ey, Onegina, Ak, Shvedova, Ag, Beniashvili, Ds, Burminsky, Ta, Lepilkina, Ss, Potanin |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
1997-7298 |
| Popis: |
Our study was based on the hypothesis that a non competitive antagonist of NMDA receptors can improve clinical effects of antipsychotic therapy in a subgroup of patients with schizophrenia with clinical signs of glutamatergic hyperfunction such as catatonic symptoms and disorganization. The study design was open and non-comparative. The duration of the study for each patient was 6 months, the target dosage of acatinol was 20 mg. Forty stable patients with schizophrenia with predominance of signs of disorganization and subcatatonic symptoms were included. The following instruments were used: PANSS, NSA, CGI, BACS, UKU. Adding of acatinol to the antipsychotic treatment improved clinical symptoms, cognitive functioning and social functioning and decreased the number of side effects. The drug was well-tolerated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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