| Autor: |
Andrew J, Song, Keyue, Ding, Iyad, Alnahhas, Normand J, Laperriere, James, Perry, Warren P, Mason, Chad, Winch, Chris J, O'Callaghan, Johan J, Menten, Alba A, Brandes, Claire, Phillips, Michael F, Fay, Ryo, Nishikawa, David, Osoba, J Gregory, Cairncross, Wilson, Roa, Wolfgang, Wick, Wenyin, Shi |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Neuro-oncology Advances |
| ISSN: |
2632-2498 |
| Popis: |
Background Lymphopenia may lead to worse outcomes for glioblastoma patients. This study is a secondary analysis of the CCTG CE.6 trial evaluating the impact of chemotherapy and radiation on lymphopenia, and effects of lymphopenia on overall survival (OS). Methods CCTG CE.6 randomized elderly glioblastoma patients (≥ 65 years) to short-course radiation alone (RT) or short-course radiation with temozolomide (RT + TMZ). Lymphopenia (mild-moderate: grade 1–2; severe: grade 3–4) was defined per CTCAE v3.0, and measured at baseline, 1 week and 4 weeks post-RT. Preselected key factors for analysis included age, sex, ECOG, resection extent, MGMT methylation, Mini-Mental State Examination, and steroid use. Multinomial logistic regression and multivariable Cox regression models were used to identify lymphopenia-associated factors and association with survival. Results Five hundred and sixty-two patients were analyzed (281 RT vs 281 RT+TMZ). At baseline, both arms had similar rates of mild-moderate (21.4% vs 21.4%) and severe (3.2% vs 2.9%) lymphopenia. However, at 4 weeks post-RT, RT+TMZ was more likely to develop lymphopenia (mild-moderate: 27.9% vs 18.2%; severe: 9.3% vs 1.8%; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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