Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos
| Autor: | Ospina, Diana, Rondón-Lagos, Milena, Villegas, Victoria E., Rodriguez-Leguizamon, Giovanni |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Mesothelioma
Unclassified drug Messenger rna Interleukin 6 Review Interleukin 8 Mitogen activated protein kinase Gene High mobility group b1 protein Anaplastic lymphoma kinase Cancer risk Genomic damage Bap1 gene Mitogen activated protein kinase 3 Mitogen activated protein kinase 1 Workplace Cellular damage Cancer Cul1 gene Gene rearrangement Met gene Smoking Reactive nitrogen species Fhit gene Occupational exposure Dna damage Mesothelin Alk gene Asbestosis Fibulin 3 Transcription factor ap 1 Lung cancer Human Genetic damage Cause of death Lung alveolus cell type 2 genomic damage Lung alveolus macrophage Protein phosphorylation cellular damage Cdkn2a gene Soluble mesothelin related protein Chromosome damage Pathogenicity cancer Gene mutation Fibronectin Aquaporin 1 Epidermal growth factor receptor Genetic predisposition Asbestos Nf2 gene occupational exposure Nonhuman Fibrogenesis Fragile histidine triad protein Immunoglobulin enhancer binding protein Oxidative stress Cyclin dependent kinase inhibitor 2b Mapk signaling Cyclin dependent kinase inhibitor 2a Osteopontin Angiogenesis Cdkn2b gene Fibulin Reactive oxygen metabolite |
| Zdroj: | Cancer Management and Research Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| ISSN: | 1179-1322 |
| Popis: | Asbestos is one of the most important occupational carcinogens. Currently, about 125 million people worldwide are exposed to asbestos in the workplace. According to global estimates, at least 107,000 people die each year from lung cancer, mesothelioma, and asbestosis as a result of occupational exposure to asbestos. The high pathogenicity of this material is currently known, being associated with the development of pulmonary diseases, of which lung cancer is the main cause of death due to exposure to this mineral. Pulmonary diseases related to asbestos are a common clinical problem and a major health concern worldwide. Extensive research has identified many important pathogenic mechanisms; however, the precise molecular mechanisms involved, and the generated genomic damage that lead to the development of these diseases, are not completely understood. The modes of action that underlie this type of disease seem to differ depending on the type of fiber, lung clearance, and genetics. This evidences the need to increase our knowledge about these effects on human health. This review focuses on the characteristics of asbestos and the cellular and genomic damage generated in humans via exposure. © 2019 Zhang et al. |
| Databáze: | OpenAIRE |
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