Lack of association between polymorphisms of the dopamine D-4 receptor gene and personality
| Autor: | Strobel, A, Spinath, FM, Angleitner, Alois, Riemann, Rainer, Lesch, KP |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Self-Assessment Adolescent novelty seeking polymorphism Extraversion Psychological ddc:150 Dopamine Polymorphism DRD4 exon III –521C/T Association Personality Novelty seeking Extraversion Surveys and Questionnaires mental disorders Humans ddc:610 521 C/T Aged DRD4 exon III Polymorphism Genetic Receptors Dopamine D2 Dopamin Polymorphie Dopamin D4-Rezeptor Assoziation Persönlichkeit Suche nach Neuem Extraversion Receptors Dopamine D4 association Exons Middle Aged personality extraversion Exploratory Behavior dopamine |
| Zdroj: | Neuropsychobiology 2003;47:52–56, ISSN: 0302-282X |
| DOI: | 10.1159/000068876 |
| Popis: | Recent studies have suggested a role of two polymorphisms of the dopamine D4 receptor gene (DRD4 exon III and –521C/T) in the modulation of personality traits such as ‘novelty seeking’ or ‘extraversion’, which are supposed to be modulated by individual differences in dopaminergic function. However, several replication studies have not provided positive findings. The present study was performed to further investigate whether DRD4 exon III and –521C/T are associated with individual differences in personality. One hundred and fifteen healthy German volunteers completed the NEO-Five-Factor Inventory (NEO-FFI) and were genotyped for the two DRD4 polymorphisms. We found no association between DRD4exon III and –521C/T, respectively, and estimated novelty seeking, NEO-FFI extraversion or other personality factors. Our findings are in line with several earlier studies which have failed to replicate the initial association results. Hence, our data do not provide evidence for a role of DRD4 exon III and the –521C/T polymorphism in the modulation of novelty seeking and extraversion. Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|