Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo

Autor:	Coto, V., D Alessandro, L., Grattarola, G., Imparato, L., Lingetti, M., Mancini, M., Nolfe, G., Franco Rengo
Přispěvatelé:	Coto, V, D'Alessandro, L, Grattarola, G, Imparato, L, Lingetti, M, Mancini, M, Nolfe, G, Rengo, Franco
Rok vydání:	1992
Předmět:	Male Analysis of Variance Arteriosclerosis Administration Oral Arterial Occlusive Diseases Stereoisomerism Intermittent Claudication Middle Aged Carnitine Humans Patient Compliance Regression Analysis Female Diabetic Angiopathies Aged
Zdroj:	Scopus-Elsevier
ISSN:	0378-6501
Popis:	The treatment of symptomatic chronic obstructive peripheral arteriopathies is a difficult task since it requires the prolonged administration of drugs which are often unable to correct the various pathogenetic factors reponsible for the disability. The authors, on the basis of recent studies demonstrating the rheological and vasoactive as well as metabolic activities of levocarnitine propionyl, have decided to use this substance in the treatment of arteriopathics affected by intermittent claudication. Levocarnitine propionyl administered orally to 142 arteriopathics affected by intermittent claudication was responsible for a marked increase in initial as well as absolute walking distances. It is particularly important to note that these clinical results were obtained primarily due to the metabolic activities of levocarnitine propionyl.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::289e4a8fb7a64f21a7be2e1df31665f2 https://pubmed.ncbi.nlm.nih.gov/1600865 Zobrazit plný text záznamu