Trimetazidine Reduces Endogenous Free Fatty Acid Oxidation and Improves Myocardial Efficiency in Obese Humans
| Autor: | Marco, Bucci, Ronald, Borra, Kjell, Någren, Jussi P, Pärkkä, Silvia, Del Ry, Romina, Maggio, Helena, Tuunanen, Tapio, Viljanen, Manuela, Cabiati, Sara, Rigazio, Markku, Taittonen, Uberto, Pagotto, Riitta, Parkkola, Lionel H, Opie, Pirjo, Nuutila, Juhani, Knuuti, Patricia, Iozzo |
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| Přispěvatelé: | Bucci M, Borra R, Någren K, Pärkkä JP, Del Ry S, Maggio R, Tuunanen H, Viljanen T, Cabiati M, Rigazio S, Taittonen M, Pagotto U, Parkkola R, Opie LH, Nuutila P, Knuuti J, Iozzo P |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Magnetic Resonance Spectroscopy Vasodilator Agents Hemodynamics Palmitates Trimetazidine Fatty Acids Nonesterified Middle Aged Lipid Metabolism Body Mass Index Glucose Positron-Emission Tomography Heart Function Tests Humans Female Obesity Fatty acid oxidation Imaging Myocardial metabolism Obesity Trimetazidine Triglyceride turnover Aged |
| Popis: | Introduction: The metabolic modulator trimetazidine (TMZ) has been suggested to induce a metabolic shift from myocardial fatty acid oxidation (FAO) to glucose utilization, but this mechanism remains unproven in humans. The oxidation of plasma derived FA is commonly measured in humans, whereas the contribution of FA from triglycerides stored in the myocardium has been poorly characterized. Aims: To verify the hypothesis that TMZ induces a metabolic shift, we combined positron emission tomography (PET) and magnetic resonance spectroscopy (H-1-MRS) to measure myocardial FAO from plasma and intracellular lipids, and myocardial glucose metabolism. Nine obese subjects were studied before and after 1 month of TMZ treatment. Myocardial glucose and FA metabolism were assessed by PET with F-18-fluorodeoxyglucose and C-11-palmitate. H-1-MRS was used to measure myocardial lipids, the latter being integrated into the PET data analysis to quantify myocardial triglyceride turnover. Results: Myocardial FAO derived from intracellular lipids was at least equal to that of plasma FAs (P= NS). BMI and cardiac work were positively associated with the oxidation of plasma derived FA (P |
| Databáze: | OpenAIRE |
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