Periostin and Epithelial-Mesenchymal Transition Score as Novel Prognostic Markers for Leiomyosarcoma, Myxofibrosarcoma, and Undifferentiated Pleomorphic Sarcoma
| Autor: | Piano, M. A., Brunello, A., Cappellesso, R., Bianco, P. D., Mattiolo, A., Fritegotto, C., Montini, B., Zamuner, C., Fiore, P. D., Rastrelli, M., Sommariva, A., de Salvo, G. L., Montesco, M. C., Rossi, C. R., Zagonel, V., Calabro, M. L. |
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| Rok vydání: | 2019 |
| Předmět: |
Leiomyosarcoma
Male Epithelial-Mesenchymal Transition Fibrosarcoma Pilot Projects Soft Tissue Neoplasms Prognosis Gene Expression Regulation Neoplastic Survival Rate Tissue Array Analysis Biomarkers Tumor Humans Female Prospective Studies Cell Adhesion Molecules Aged Follow-Up Studies Retrospective Studies |
| Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 26(12) |
| ISSN: | 1557-3265 |
| Popis: | Interpatient clinical variability in soft-tissue sarcomas (STS) highlights the need for novel prognostic markers supporting patient risk stratification. As sarcomas might exhibit a more mesenchymal or a more epithelial state, we focused on epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT/MET) for prognostic clues, and selected three histotypes with variable aggressiveness.The expression of EMT/MET-related factors was measured by qRT-PCR in 55 tumor samples from patients with leiomyosarcoma, myxofibrosarcoma, or undifferentiated pleomorphic sarcoma. The identified marker was further evaluated by IHC in 31 leiomyosarcomas and by measuring its circulating levels in 67 patients. The prognostic value of a sarcoma-tailored EMT score was analyzed. Epirubicin chemosensitivity and migration were studied in primary STS cultures. Associations with overall survival (OS) were assessed using Kaplan-Meier and Cox regression methods.High expression of periostin, a mesenchymal matricellular protein, in sarcoma tissues (Although limited to a pilot study, these findings suggest that periostin might contribute prognostic information in the three studied STS histotypes. Moreover, a transitioning EMT score measured in the tumor might predict a less active and a more chemosensitive disease. |
| Databáze: | OpenAIRE |
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