The impact of medicinal drugs on traffic safety: a systematic review of epidemiological studies

Autor: Ludivine, Orriols, Louis-Rachid, Salmi, Pierre, Philip, Nicholas, Moore, Bernard, Delorme, Anne, Castot, Emmanuel, Lagarde
Přispěvatelé: Mouillet, Evelyne, Epidémiologie et Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2, Clinique du sommeil, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Département de Pharmacologie, Université Bordeaux Segalen - Bordeaux 2, Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS), AFSSAPS
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Pharmacoepidemiology and Drug Safety
Pharmacoepidemiology and Drug Safety, Wiley, 2009, 18 (8), pp.647-58. ⟨10.1002/pds.1763⟩
ISSN: 1053-8569
1099-1557
DOI: 10.1002/pds.1763⟩
Popis: International audience; Purpose To evaluate the quality of epidemiological research into effects of medicinal drugs on traffic safety and the current knowledge in this area. Data sources The bibliographic search was done in Medline electronic database using the keywords: ((accident* or crash*) and traffic and drug*) leading to 1141 references. Additional references were retrieved from the Safetylit website and the reference lists of selected studies. Original articles published in English or French, between 1 April 1979 and 31 July 2008, were considered for inclusion. We excluded descriptive studies, studies limited to alcohol or illicit drug involvement and investigations of injuries other than from traffic crashes. Studies based on laboratory tests, driving simulators or on-the-road driving tests were also excluded. Eligible studies had to evaluate the causal relationship between the use of medicinal drugs and the risk of traffic crashes. Study quality was assessed by two independent experts, according to a grid adapted from the strengthening the reporting of observational studies in epidemiology (STROBE) statement. Results Twenty two studies of variable methodological quality were included. Definition of drug exposure varied across studies and depended on the data sources. Potential confounding due to the interaction between the effects of the medicinal drug and disease-related symptoms was often not controlled. The risk of motor-vehicle crashes related to benzodiazepines has been amply studied and demonstrated. Results for other medicinal drugs remain controversial. Conclusion There is a need for large studies, investigating the role of individual substances in the risk of road traffic crashes.
Databáze: OpenAIRE
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