Genetic Attributes of Blood-Derived Subtype-C HIV-1 tat and env in India and Neurocognitive Function
| Autor: | Tilghman, Myres W, Bhattacharya, Jayanta, Deshpande, Suprit, Ghate, Manisha, Espitia, Stephen, Grant, Igor, Marcotte, Thomas D, Smith, Davey, Mehendale, Sanjay |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male impairment AIDS Dementia Complex Genotype India HIV Infections Microbiology Article env Gene Products Cohort Studies Gene Frequency Clinical Research residue Virology Genetics Humans Codon Neurosciences env Gene Products Human Immunodeficiency Virus virus diseases DNA Sequence Analysis DNA sequence neuropsychological testing Good Health and Well Being Medical Microbiology HIV-1 HIV/AIDS Female tat Gene Products Human Immunodeficiency Virus tat Gene Products Infection Sequence Analysis Human Immunodeficiency Virus signature clade C |
| Zdroj: | Journal of medical virology, vol 86, iss 1 |
| Popis: | Genetic elements in HIV-1 subtype B tat and env are associated with neurotoxicity yet less is known about other subtypes. HIV-1 subtype C tat and env sequences were analyzed to determine viral genetic elements associated with neurocognitive impairment in a large Indian cohort. Population-based sequences of HIV-1 tat (exon 1) and env (C2-V3 coding region) were generated from blood plasma of HIV-infected patients in Pune, India. Participants were classified as cognitively normal or impaired based on neuropsychological assessment. Tests for signature residues, positive and negative selection, entropy, and ambiguous bases were performed using tools available through Los Alamos National Laboratory (http://www.hiv.lanl.gov) and Datamonkey (http://www.datamonkey.org). HIV-1 subtype C tat and env sequences were analyzed for 155 and 160 participants, of which 34-36% were impaired. Two signature residues were unique to impaired participants in exon 1 of tat at codons 29 (arginine) and 68 (proline). Positive selection was noted at codon 29 among normal participants and at codon 68 in both groups. The signature at codon 29 was also a signature for low CD4+ ( |
| Databáze: | OpenAIRE |
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