Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
| Autor: | Kara-Terki, Lyna, Treps, Lucas, Blanquart, Christophe, Fradin, Delphine |
|---|---|
| Přispěvatelé: | Immunogenic Cell Death and Mesothelioma Therapy (CRCINA-ÉQUIPE 4), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Leuven Center for Cancer Biology (VIB-KU-CCB), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Vlaams Instituut voor Biotechnologie [Ghent, Belgique] (VIB), Ligue contre le Cancer, comités 16, 22, 29, 35, 44, 56Cancéropole Grand Ouest—AO Structurant-ExomiRBettencourt Schueller FoundationResearch Foundation Flanders (FWO), ANR-11-LABX-0016,IGO,Immunothérapies Grand Ouest(2011), Bernardo, Elizabeth, Laboratoires d'excellence - Immunothérapies Grand Ouest - - IGO2011 - ANR-11-LABX-0016 - LABX - VALID, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Clinical Trials as Topic
Lung Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer Review Thoracic Neoplasms Prognosis lcsh:Chemistry Gene Expression Regulation Neoplastic Extracellular Vesicles MicroRNAs lung cancer lcsh:Biology (General) lcsh:QD1-999 [SDV.CAN] Life Sciences [q-bio]/Cancer mesothelioma Biomarkers Tumor Tumor Microenvironment Humans exosome lcsh:QH301-705.5 miRNA |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2020, 21 (17), pp.6024. ⟨10.3390/ijms21176024⟩ International Journal of Molecular Sciences, 2020, 21 (17), pp.6024. ⟨10.3390/ijms21176024⟩ International Journal of Molecular Sciences, Vol 21, Iss 6024, p 6024 (2020) |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | International audience; Extracellular vesicles (EVs), such as exosomes, are critical mediators of intercellular communication between tumor cells and other cells located in the microenvironment but also in more distant sites. Exosomes are small EVs that can carry a variety of molecules, such as lipids, proteins, and non-coding RNA, especially microRNAs (miRNAs). In thoracic cancers, including lung cancers and malignant pleural mesothelioma, EVs contribute to the immune-suppressive tumor microenvironment and to tumor growth and metastasis. In this review, we discuss the recent understanding of how exosomes behave in thoracic cancers and how and why they are promising liquid biomarkers for diagnosis, prognosis, and therapy, with a special focus on exosomal miRNAs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|