Age-dependent effects of bed rest in human skeletal muscle: exercise to the rescue
| Autor: | Moreira, Jose B. N., Wohlwend, Martin, Åmellem, Ingrid, Jannig, Paulo R. |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Aging Journal Club Ubiquitin-Protein Ligases Muscle Proteins AMP-Activated Protein Kinases Exercise Therapy Tripartite Motif Proteins Young Adult Thinness Protein Biosynthesis Proteolysis Humans Muscle Female Amino Acids Essential RNA Messenger Muscle Skeletal Microtubule-Associated Proteins Exercise Bed Rest Biomarkers Aged |
| Zdroj: | The Journal of physiology. 594(2) |
| ISSN: | 1469-7793 |
| Popis: | Bed rest-induced muscle loss and impaired muscle recovery may contribute to age-related sarcopenia. It is unknown if there are age-related differences in muscle mass and muscle anabolic and catabolic responses to bed rest. A secondary objective was to determine if rehabilitation could reverse bed rest responses. Nine older and fourteen young adults participated in a 5-day bed rest challenge (BED REST). This was followed by 8 weeks of high intensity resistance exercise (REHAB). Leg lean mass (via dual-energy X-ray absorptiometry; DXA) and strength were determined. Muscle biopsies were collected during a constant stable isotope infusion in the postabsorptive state and after essential amino acid (EAA) ingestion on three occasions: before (PRE), after bed rest and after rehabilitation. Samples were assessed for protein synthesis, mTORC1 signalling, REDD1/2 expression and molecular markers related to muscle proteolysis (MURF1, MAFBX, AMPKα, LC3II/I, Beclin1). We found that leg lean mass and strength decreased in older but not younger adults after bedrest (P |
| Databáze: | OpenAIRE |
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