HIV-Related Arterial Stiffness in Malawian Adults Is Associated With the Proportion of PD-1–Expressing CD8+ T Cells and Reverses With Antiretroviral Therapy

Autor:	Kelly, Christine, Mwandumba, Henry C, Heyderman, Robert S, Jambo, Kondwani, Kamng’ona, Raphael, Chammudzi, Mishek, Sheha, Irene, Peterson, Ingrid, Rapala, Alicja, Mallewa, Jane, Walker, A Sarah, Klein, Nigel, Khoo, Saye
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	sub-Saharan Africa Adult Male endothelial damage Malawi Programmed Cell Death 1 Receptor HIV HIV Infections CD8-Positive T-Lymphocytes Major Articles and Brief Reports arterial stiffness Vascular Stiffness Anti-Retroviral Agents cardiovascular disease T-cell exhaustion PD-1 HIV/AIDS Humans
Zdroj:	The Journal of Infectious Diseases
ISSN:	1537-6613 0022-1899
Popis:	Background The contribution of immune activation to arterial stiffness and its reversibility in human immunodeficiency virus (HIV)–infected adults in sub-Saharan Africa is unknown. Methods HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with a CD4+ T-cell count of Arterial stiffness is increased in Malawian adults with low CD4 during the first 3 months of antiretroviral therapy, compared to adults without HIV. Hypertension is an important traditional risk factor and immune activation, including CD8 exhaustion, also contributes to arterial stiffness.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ffd52a5ea7e7508b460c018c9500cd5e http://europepmc.org/articles/PMC6534190 Zobrazit plný text záznamu