[Study on the association of lecithin cholesterol acyltransferase gene polymorphisms with the lipid metabolism in coronary atherosclerotic heart disease]
| Autor: | Kelan, Zhang, Sizhong, Zhang, Keqin, Zheng, Yong, He, Li, Zhang, Zhiguang, Su, Yan, Sun, Jiajun, Shi, Xiangdong, Kong, Yu, Tong |
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| Rok vydání: | 2003 |
| Předmět: |
Male
China Polymorphism Genetic Genotype Cholesterol HDL Cholesterol VLDL Cholesterol LDL Coronary Artery Disease DNA DNA Restriction Enzymes Middle Aged Lipid Metabolism Lipids Phosphatidylcholine-Sterol O-Acyltransferase Cholesterol Gene Frequency Humans Female Alleles Polymorphism Restriction Fragment Length Triglycerides |
| Zdroj: | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 20(2) |
| ISSN: | 1003-9406 |
| Popis: | To examine the distribution of 3 polymorphisms of lecithin cholesterol acyltransferase gene in Chinese population and the association of these polymorphisms with lipid metabolism in patients with atherosclerotic heart disease (CHD).Genotypes and frequencies of 3 sites were examined by PCR-restriction fragment length polymorphism technique in 209 unrelated normal control individuals and 203 CHD patients.The observed allele frequencies conform well to Hardy-Weinberg equilibrium. The frequency of 608T allele was significantly higher in controls than that in patients (P=0.034). Compared with the CHD patients without 608T, the CHD patients with 608T exhibited a significant increase in plasma HDL-C concentration (P=0.015). 911T/C and 1188C/T polymorphisms were not found in either group.608T polymorphism of LCAT gene was associated with higher plasma HDL-C level in CHD patients, while 911T/C and 1188C/T polymorphisms maybe very rare in Chinese population. |
| Databáze: | OpenAIRE |
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