Clobetasol propionate followed by calcipotriol is superior to calcipotriol alone in topical treatment of psoriasis
| Autor: | J, Austad, J R, Bjerke, B T, Gjertsen, S, Helland, J K, Livden, T, Morken, N J, Mørk |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Adolescent Administration Topical Anti-Inflammatory Agents Severity of Illness Index Calcitriol Double-Blind Method Humans Psoriasis Physician's Role Glucocorticoids Purpura Aged Skin Clobetasol Pruritus Middle Aged Treatment Outcome Patient Satisfaction Dermatitis Irritant Drug Therapy Combination Female Dermatologic Agents Follow-Up Studies Program Evaluation |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology : JEADV. 11(1) |
| ISSN: | 0926-9959 |
| Popis: | Although potent, topical corticosteroids offer effective and rapid healing of psoriatic lesions. Their long term use is limited because of the risk of side effects. Calcipotriol is safe for long-term treatment, but its initial efficacy is lower than with topical corticosteroids.To investigate whether 2 weeks of treatment with clobetasol propionate 0.05% ointment bd followed by 4 weeks of treatment with calcipotriol 50 microg/g bd would offer therapeutic advantages over 6 weeks of continuous treatment with calcipotriol.Forty-nine patients with moderate to severe plaque psoriasis were recruited from five centres in Norway. In a randomised, double-blind, right- versus left-side comparison, ointments were applied to two symmetrically-located areas.Two weeks of treatment with clobetasol propionate produced a significantly greater decrease in total symptom score (combined scores of erythema, induration and scaling) than calcipotriol treatment (P0.0001). This improvement on the clobetasol propionate-treated side of the body was maintained throughout a subsequent 4-week treatment period when calcipotriol was applied to both sides of the body (P0.0001). The superiority of the clobetasol propionate followed by calcipotriol treatment was maintained during a 4-week, treatment-free, observation period. Treatments were well tolerated with no rebound effect.Clobetasol propionate ointment bd for 2 weeks followed by treatment with calcipotriol ointment bd for 4 weeks was superior to calcipotriol ointment alone in the treatment of plaque psoriasis. |
| Databáze: | OpenAIRE |
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