Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients
| Autor: | V F, Chekhun, V E, Zhylchuk, N Yu, Lukyanova, A L, Vorontsova, Yu I, Kudryavets |
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| Rok vydání: | 2009 |
| Předmět: |
Receptor
ErbB-2 Gene Expression Breast Neoplasms Immunohistochemistry Survival Analysis Receptors Estrogen Drug Resistance Neoplasm Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Humans Female Metallothionein ATP Binding Cassette Transporter Subfamily B Member 1 Receptors Progesterone Glutathione Transferase |
| Zdroj: | Experimental oncology. 31(2) |
| ISSN: | 1812-9269 |
| Popis: | To evaluate the efficacy of the application of various chemotherapy schemes based on the immunohistochemical study of expression patterns of proteins associated with the drug resistance P-glycoprotein (P-gp), glutathione-S-transferase (GST), metallothioneins (MT) of breast cancer (BC) patients with the triple-receptor-negative (RE(-), RP(-), HER-2/neu(-)) cancer.P-gp, GST and MT expression in BC-biopsy samples from 60 BC patients was evaluated by immunohistochemical analysis. The results of the clinical observations showed that 3-years relapse-free survival rate of the patients of with P-gp, GST and MT-positive tumors treated with taxoter + adriablastin / taxoter + cyclophosphamide (TA/TC), gemcitabine + carboplatin, or TC + bevacizumab was 61.5%, 78.6% and 81.2% respectively, vs 41.2% in the control group with P-gp, GST and MT-negative tumors treated with adriablastin + cyclophosphamide (p0.05), while overrall suvival rates were 84.4%, 92.6% and 93.8% respectively vs 70.6% in the control group (p0.05).The study points on the possibility to elevate the efficiency of polychemotherapy by its individualization based on the expression patterns of P-gp, GST and MT on tumor cells of the patients with the triple-receptor-negative BC. |
| Databáze: | OpenAIRE |
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