| Autor: |
L B, Katz, R J, Capetola, D C, Argentieri, L E, Moore, T, Genna, M C, Porter, V, Jasty, R E, Hartnagel, D, Abrutyn, D A, Shriver |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
The Journal of rheumatology. 13(5) |
| ISSN: |
0315-162X |
| Popis: |
Gastrointestinal irritation is the most significant side effect in patients chronically taking nonsteroidal antiinflammatory drugs (NSAID) for treatment of arthritic conditions. Rioprostil, a primary alcohol prostaglandin E1 analog, prevents gastric bleeding induced by several NSAID in a rat model of arthritis that is similar in many aspects to human rheumatoid arthritis. Daily oral dosing of rioprostil (50 micrograms/kg BID for 15 days) did not influence the course of the adjuvant disease in rats or alter the antiinflammatory or analgesic effect of the NSAID. In a 13 week efficacy study in dogs, rioprostil (40-60 micrograms/kg, PO) completely prevented gastric hemorrhagic lesions induced by daily administration of aspirin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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