Effect of sera of cirrhotic patients with or without hepatitis B virus infection on protein synthesis in hepatoma cells

Autor: V, Hajnická, A, Volná, D, Stancek, M, Oltman
Rok vydání: 1994
Předmět:
Zdroj: Acta virologica. 38(1)
ISSN: 0001-723X
Popis: The in vitro effects of sera of 11 patients with liver cirrhosis on protein synthesis in PLC/PRF/5 cells were studied. Hepatitis B virus (HBV) infection was documented in 7 patients. Increased random production of several cell proteins of M(r) of approximately 25, 65, 90 and 130 K was shown by SDS-polyacrylamide gel electrophoresis (SDS-PAGE). There was no correlation between HBV-positive and HBV-negative cirrhosis and the induced proteins. One of them was identified as alpha-1 foetoprotein by immunoblot analysis. C-reactive protein (CRP) was determined only in one case; production of interleukin-6 (IL-6) was not detected.
Databáze: OpenAIRE