| Autor: |
Christopher M, Davenport, Rajit, Rajappa, Ljudmila, Katchan, Charlotte R, Taylor, Ming-Chi, Tsai, Caleb M, Smith, Johannes W, de Jong, Don B, Arnold, Stephan, Lammel, Richard H, Kramer |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Neuron. 109(1) |
| ISSN: |
1097-4199 |
| Popis: |
The excitatory synapse between hippocampal CA3 and CA1 pyramidal neurons exhibits long-term potentiation (LTP), a positive feedback process implicated in learning and memory in which postsynaptic depolarization strengthens synapses, promoting further depolarization. Without mechanisms for interrupting positive feedback, excitatory synapses could strengthen inexorably, corrupting memory storage. Here, we reveal a hidden form of inhibitory synaptic plasticity that prevents accumulation of excitatory LTP. We developed a knockin mouse that allows optical control of endogenous α5-subunit-containing γ-aminobutyric acid (GABA) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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