| Autor: |
Mayank Mohan, Agarwal, ShivKumar, Patil, Kishore, Roy, Mayur, Bandawar, Sunirmal, Choudhury, Ravimohan, Mavuduru, Suresh K, Sharma, Arup K, Mandal, Shrawan K, Singh |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Neurourology and urodynamics. 33(1) |
| ISSN: |
1520-6777 |
| Popis: |
We intended to define volume-normalized flow rates (cQ; VQI) and to construct and validate uroflow (Q)-volume (V) nomograms in our Indian (non-Caucasian) population.Prospective observational study.Group A, male healthy volunteers 18-45 years without LUTS. Group B, men18 years with LUTS (IPSS 7; global QOL 2). The participants voided in standing on normal-to-strong desire into digital gravimetric uroflowmeter. Data of50 ml void and intermittent flow was discarded. Reference cQ calculated using (i) Von Garrelts equations (=Q/VV(2)), (ii) cubic equations (=Q/VV(3)). Bladder volume (BV) rather than voided volume (VV) was considered for Q-V relation (BV = VV + PVR). VQI derived from present data were compared with the reference-VQI in terms of differences in area-under-curve of receiver operating characteristics. For comparing sensitivity, specificity and predictive values of study nomograms with Caucasian nomograms (Liverpool and Siroky), data of group-A and -B were plotted on each nomogram and no. of observations above and below the cutoffs (defined as equivalent to -1 SD) manually counted.Total 542 voids of group-A and 465 of group-B included for final analysis. Q-V relation was best described as [Q ∝ BV(2.4) ≅ BV(2)]. The derived VQI (=Q/BV(2.4) ≅ Q/BV(2)) fared significantly superior to reference VQI with VV as denominator. Nomograms, constructed on Q ∝ BV(2) , were less sensitive but had higher specificity and positive predictive values compared to Caucasian nomograms.Volume-normalized flow-rate index with BV as denominator (Q/BV(2)) is has highly discriminative value in screening for voiding dysfunction. Population-specific Q-BV nomograms are more specific and predictive than Caucasian Q-VV nomograms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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