[The determination of the antigenic determinant of protective monoclonal antibodies specific to the Francisella tularensis lipopolysaccharide]

Autor:	V S, Khlebnikov, I R, Golovlev, N V, Tokhtamysheva, S F, Averin, D P, Kulevatskiĭ, G K, Grechko, A A, Averina, S S, Vetchinin
Rok vydání:	1993
Předmět:	Lipopolysaccharides Mice Inbred BALB C Hybridomas Virulence Antibodies Monoclonal Antibodies Bacterial Epitopes Mice Antibody Specificity Immunologic Techniques Animals Binding Sites Antibody Serial Passage Francisella tularensis
Zdroj:	Zhurnal mikrobiologii, epidemiologii i immunobiologii. (1)
ISSN:	0372-9311
Popis:	F. tularensis lipopolysaccharide (LPS) was studied with the use of monoclonal antibodies (McAb) having protective properties. The binding site of these McAb (IgG2a) is localized on the O-chain of LPS. In contrast to LPS isolated from vaccine strain 15, LPS isolated from F. tularensis cells in the R-form has no O-chains and does not interact with McAb.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fac514a9505c5b0350dad909ba89b5d2 https://pubmed.ncbi.nlm.nih.gov/7520655 Zobrazit plný text záznamu