| Autor: |
Yiwei, Hu, Huiting, Qu, Jie, He, Hongyao, Zhong, Shoukai, He, Peng, Zhao, Leyao, Zhang, Jinghua, Chen, Chao, Deng |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Die Pharmazie. 77(3) |
| ISSN: |
0031-7144 |
| Popis: |
Exosomes are a type of nanoparticles in 40-200 nm extracellular vesicles secreted from living cells, containing a plurality of biologically active substances, which can be used as carriers of intercellular delivery signals. Among them, mesenchymal stem cell (MSC)-derived exosomes have been reported to play important roles in injury repair, alleviating inflammation; thus, MSC-derived exosomes have become hot spot in noncellular therapies. The role of human placental MSC-derived exosomes (hplMSC-Exos) in inflammation and their potential mechanisms are unclear. Therefore, we investigated the anti-inflammatory effects of hplMSC-Exos in lipopolysaccharide (LPS)-induced RAW264.7 cells and their intrinsic mechanisms. Our data demonstrated that hplMSCs-Exos can adjust inflammation by regulating TLR4-mediated NF-κB/MAPK and PI3K signaling pathways, indicating that hplMSCs-Exos can act as a new strategy for inflammatory treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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