| Autor: |
T L, Petty, G W, Silvers, R E, Stanford |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
The American review of respiratory disease. 125(5) |
| ISSN: |
0003-0805 |
| Popis: |
Pulmonary function tests were obtained in 7 emphysema-free and 27 emphysematous lungs with minimal small airway disease. The lungs were divided into 2 groups on the basis of whether they had a small or large, i.e., increased closing capacity. The lungs were subsequently fixed and the small airways (less than or equal to 2.00 mm) from 6 to 10 blocks of tissue were counted and inside diameters were measured. There was a significant increase in the number of airways measuring 0.40 mm or less (p less than 0.03) and a decrease of airways measuring 0.81 to 1.0 mm (p less than 0.03) in the lungs that had larger closing capacities. When the data of both groups were combined there was a negative correlation between the mean bronchiole inside diameter as a function of the percentage of predicted closing capacity (r = -0.381, p less than 0.03) and a positive correlation between small airway inside diameter and the forced expiratory volume in one second (r = 0.595, p less than 0.001) and the maximal mid-expiratory flow rate (r = 0.527, p less than 0.01). We conclude that in lungs that are normal or involved with minimal lung disease, function can be related to the caliber of the small airways. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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