The influence of co-morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastro-oesophageal reflux disease

Autor:	B, Nojkov, J H, Rubenstein, S A, Adlis, M J, Shaw, R, Saad, J, Rai, B, Weinman, W D, Chey
Rok vydání:	2008
Předmět:	Adult Male Adolescent Proton Pump Inhibitors Middle Aged Proton Pumps 2-Pyridinylmethylsulfinylbenzimidazoles Irritable Bowel Syndrome Heartburn Stress Physiological Rabeprazole Gastroesophageal Reflux Quality of Life Humans Female Aged
Zdroj:	Alimentary pharmacologytherapeutics. 27(6)
ISSN:	1365-2036
Popis:	A subset of patients with gastro-oesophageal reflux disease (GERD) does not achieve complete symptom resolution with proton pump inhibitor (PPI) therapy. The factors which affect response to PPI therapy in GERD patients remain unclear.To determine the prevalence and impact of irritable bowel syndrome (IBS) and psychological distress (PD) on GERD symptoms and disease-specific quality of life (QoL) before and after PPI therapy and to assess the same outcomes before and after PPI therapy in non-erosive reflux disease (NERD) and erosive oesophagitis (EO) GERD patients.Patients undergoing oesophago-gastroduodenoscopy (OGD) for heartburn were recruited. Participants completed validated surveys: Digestive Health Symptom Index, Reflux Disease Questionnaire, Quality of Life in Reflux and Dyspepsia and Brief Symptom Inventory (BSI). IBS was defined as3 Manning criteria and PD as BSI score63. At OGD, patients were classified as NERD or EO. Patients were treated with rabeprazole 20 mg/day for 8 weeks before completing follow-up surveys.Of 132 GERD patients enrolled, 101 completed the study. The prevalence rates of IBS and PD were 36% and 41%, respectively. IBS independently predicted worse QoL before and after PPI therapy. PD independently predicted worse GERD symptoms and QoL before and after PPI therapy. There were no differences in symptoms or QoL between NERD and EO patients before or after PPI therapy.IBS and PD impacted GERD symptoms and QoL before and after PPI therapy. Symptoms and QoL before and after PPI therapy were similar in NERD and EO patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f4a26a25d56646d05f7ad23b217cbfe7 https://pubmed.ncbi.nlm.nih.gov/18194508 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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