Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus

Autor: Andrew J, Fritz, A Rasim, Barutcu, Lori, Martin-Buley, André J, van Wijnen, Sayyed K, Zaidi, Anthony N, Imbalzano, Jane B, Lian, Janet L, Stein, Gary S, Stein
Rok vydání: 2015
Předmět:
Zdroj: Journal of cellular biochemistry. 117(1)
ISSN: 1097-4644
Popis: The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear-structure building blocks in directly supporting nuclear function in a physiologically responsive manner.
Databáze: OpenAIRE