[Comparative evaluation of the antiradical and antioxidant activity of estrogens and their nitro derivatives]

Autor:	A I, Matiushin, V M, Gukasov, V M, Rzheznikov, V Iu, Balaban'ian, M A, Boĭko
Rok vydání:	2002
Předmět:	Male Free Radicals Myocardium Estrogens In Vitro Techniques Egg Yolk Antioxidants Rats Structure-Activity Relationship Liposomes Luminescent Measurements Benzene Derivatives Animals Female Lipid Peroxidation Oxidation-Reduction
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 65(3)
ISSN:	0869-2092
Popis:	Estradiol, ethynylestradiol, and estradiol acetate possess antiradical activity (K7 = (1.8-2.0) x 10(-4) liter/mole sec). Nistranol exhibits antiradical properties only upon acid hydrolysis. The results of experiments with egg yolk liposomes showed evidence of a pronounced antioxidant activity of estradiol, ethynylestradiol, and estradiol nitrate, and the absence of such activity in nistranol. In the experiments on rat heart homogenates, nitroestrogens in a concentration of about 10(-4) M reduced the level of TBA-active products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f2f58fabf18d43080ba0265e8234dc9c https://pubmed.ncbi.nlm.nih.gov/12227090 Zobrazit plný text záznamu